Director, In Vivo Pharmacology

Responsibilities

• Represent the in vivo pharmacology function on drug discovery project teams, specifically supporting assets in obesity and metabolic diseases
• Identify and implement in vivo efficacy and PK/PD models to support the assessment of lead small molecules, antibodies, peptides, and genetic modalities
• Collaborate across functions including in vitro pharmacology, DMPK/Tox, and translational sciences to advance programs toward IND-enabling studies
• Manage direct reports to execute internal studies and oversee studies at external CROs to achieve program goals
• Participate in strategic partnerships and collaborations with Flagship Platform companies and external pharmaceutical partners
• Contribute to the development of comprehensive in vivo strategic plans and research strategies

Requirements

• PhD with 10+ years of industry experience or MS with 12+ years of industry experience in in vivo pharmacology or a related discipline
• Strong understanding of PK/PD assessments in models of disease
• Proven experience designing ex vivo studies to assess PD and target engagement endpoints
• Proficiency with rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• In-depth hands-on expertise with in vivo models of obesity and metabolic diseases

Preferred Qualifications

• Experience with cardiovascular disease models
• Experience managing in vivo personnel in a dynamic, fast-paced research environment
• Experience working with various modalities including small molecules, antibodies, and peptides
• Familiarity with animal facility management, protocol writing, IACUC interactions, and LIMS

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• A broad range of other company benefits

About the Company

Pioneering Medicines is Flagship Pioneering’s in-house drug development unit. We are dedicated to conceiving and developing a broad portfolio of life-changing treatments built from Flagship’s innovative scientific platforms. We work to accelerate therapeutic innovation through highly co-creative strategic alliances and internal research excellence.