Director, High-Throughput Biology

Responsibilities

• Set the vision and operating model for HTB, defining strategy, success metrics, and standards
• Partner cross-functionally to align assay readiness, screening feasibility, and platform capabilities
• Lead high-throughput screening strategy and execution to drive prioritization and data-driven decisions
• Optimize team resourcing and representation across scientists and SRAs
• Lead an integrated platform organization aligning biology, automation, and data analytics
• Build, develop, and retain a high-performing team through coaching and development
• Provide hands-on technical leadership in assay strategy, screening design, and analytical methods
• Establish scalable practices through documentation and shared ownership of workflows

Requirements

• PhD in Biological Sciences, Computational Sciences, or related discipline
• 10+ years of experience in high-throughput or high-content screening environments
• Expertise with automated screening platforms (384- and/or 1536-well formats)
• Experience screening compound libraries larger than 100k
• Experience advancing drug discovery programs from hit identification through lead optimization
• Experience with microscopy-based or imaging-enabled screening platforms
• Experience with genetic screens or systems biology approaches
• Strong expertise in statistical analysis and large-scale dataset quality control
• Proficiency in Python
• Experience building or contributing to scalable data processing pipelines
• Proficiency with compound databases, LIMS, and enterprise data systems
• Proven cross-functional leadership across biology, chemistry, engineering, and data teams

Preferred Qualifications

• Experience with single-molecule imaging technology
• Experience with novel technologies or assay development for drug discovery
• Familiarity with machine learning or AI applications in phenotypic screening
• Ability to build hybrid biology and computational teams

Benefits

• 401k plan with company matching
• Medical, dental, and vision insurance (high premium coverage)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

About the Company

Eikon Therapeutics is a biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases.