Associate Scientist, Process Development

Responsibilities

• Support experimental design and execute experiments to develop and optimize manufacturing processes for genome-engineered T cell products
• Collect and analyze experimental data and present findings in team meetings to contribute to technical discussions
• Provide support across different process development areas, including the formulation of media and ribonucleic protein complexes
• Assist with process development and technology transfer of GMP manufacturing processes to internal and external organizations
• Maintain accurate and detailed laboratory notebooks and electronic records in compliance with regulatory requirements
• Assist in preparing technical documents, including standard operating procedures (SOPs), batch records, and development reports

Requirements

• BS or MS degree in Biology, Biotechnology, Biomedical Engineering, or a related field
• 2+ years of experience with a BS or 1+ years of experience with an MS
• Hands-on experience with the development of engineered TCR T cell therapies
• Hands-on experience with genome editing tools, including DNA/RNA transfection approaches
• Familiarity with cell therapy process development, including scale-up and interpretation of T-cell functional assays (flow-cytometry, cytotoxicity, proliferation)
• Experience with authoring manufacturing batch records
• Strong organizational, time management, and teamwork skills

Preferred Qualifications

• Knowledge of cGMP manufacturing and practical experience in GMP operations
• Experience with statistical analysis software such as JMP or GraphPad Prism
• Familiarity with the fundamentals of the Design of Experiments (DoE) approach

Benefits

• Competitive annual base pay
• Short-term incentive bonus opportunity
• Eligibility for equity-based long-term incentive programs
• Qualified retirement program (401(k) plan)
• Comprehensive health benefits including medical, prescription drug, dental, and vision coverage
• Paid vacation, holidays, and leaves

About the Company

AstraZeneca is a forward-thinking global BioPharmaceutical company dedicated to delivering life-changing medicines. Driven by science, we work as one collaborative team to improve patient outcomes worldwide through innovation and diversity.