Associate Director/Director, Medicinal Chemistry

Responsibilities

• Formulate medicinal chemistry strategies and utilize the Genesis platform to execute drug discovery programs from Hit ID through candidate nomination
• Use Structure-Based Drug Design (SBDD) principles to optimize physiochemical properties and interpret ADME/PK/Toxicology and biology data
• Use data visualization software and metric-based analysis to form medicinal chemistry hypotheses and prioritize strategies
• Collaborate with multidisciplinary teams including biology, DMPK, software engineers, and computational chemists to drive hypothesis-driven decisions
• Communicate and engage regularly with project team members, management, and industry collaborators

Requirements

• PhD in synthetic organic chemistry or medicinal chemistry with 8+ years of industrial drug discovery experience, OR MS in synthetic organic chemistry with 14+ years of industrial experience
• Expert medicinal chemistry knowledge with expertise in SBDD and physical property-based optimization
• Expert synthetic chemistry knowledge and problem-solving skills
• Experience with data visualization and metric-based analysis to drive prioritization
• Strong communication skills for both informal team settings and professional presentations

Benefits

• Competitive pay and stock option eligibility
• 401(k) plan and open PTO policy
• Paid company holidays
• Fully covered health care plan (Medical, Dental, and Vision) for employees
• Free lunch and snacks at the office

About the Company

Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company’s generative and predictive AI platform, GEMS, integrates AI and physics to generate and optimize drug molecules. Genesis has raised over $300 million from leading investors and is deploying its technology to advance an internal therapeutics pipeline for high-impact targets.