Associate Director - Director, In Vivo Pharmacology

Responsibilities

• Lead in vivo pharmacology strategy for customized base editor programs, spanning rodent and NHP studies from proof-of-concept through IND-enabling planning
• Design and oversee studies evaluating editing efficiency, delivery performance, tissue biodistribution, exposure, dose response, and pharmacodynamic biomarkers
• Serve as the in vivo pharmacology representative on cross-functional program teams to translate complex datasets into program recommendations
• Lead and manage external study execution with CROs and vivarium partners, including protocol development and vendor oversight
• Partner with bioanalytical, molecular biology, and computational teams to integrate NGS, ddPCR/qPCR, and histology readouts
• Build scalable in vivo pharmacology capabilities, including study design templates and data review standards
• Contribute to regulatory-facing pharmacology packages for IND-enabling development
• Mentor researchers and help establish a high-performing in vivo pharmacology function

Requirements

• PhD in pharmacology, physiology, molecular biology, genetics, bioengineering, or a related field
• 6-8 years of relevant industry experience in in vivo pharmacology and preclinical development
• Demonstrated experience designing and managing rodent and NHP pharmacology studies
• Experience with genetic medicines such as genome editing, base editing, gene therapy, or LNP delivery
• Strong understanding of PK/PD, biodistribution, and translational endpoints
• Experience leading CRO studies and vendor oversight
• Excellent communication skills for presenting strategy and data to senior leadership
• Must have ongoing US work authorization without sponsorship

About the Company

Profluent is an AI-first protein design company that develops deep generative models to design and validate novel, functional proteins to revolutionize biomedicine.